Francis Jeffrey Dilworth

This study shows PADs and mSWI/SNF chromatin remodelers reciprocally regulate each other's expression and function in skeletal muscle differentiation and regeneration.

The paper establishes dynamic enhancer-based gene regulatory networks in human hematopoiesis, revealing that stemness loss and lineage acquisition are temporally and mechanistically uncoupled.

The paper investigates how epigenetic changes in muscle stem cells from Duchenne Muscular Dystrophy patients lead to loss of myogenic identity and identifies MEF2B as a key mediator.

The paper identifies CAD-bound genes involved in both muscle cell differentiation and cancer-causing translocations, showing CAD-induced breaks are physiologic in differentiation and linked to oncogenic gene regulation.

This study shows SMCHD1 activates cell cycle genes in human myoblasts, promoting proliferation independently of DUX4, and identifies LAP2 as a key target gene.

The paper identifies self-renewing osteochondral stem cells in the postnatal skeleton and compares their transcriptomes across adult, fetal, mouse, and human samples.

This study shows that SATB2 removal, mediated by caspase 7 cleavage, is critical for chromatin reorganization during myoblast differentiation.

This study shows that bromodomains in BRG1 and BRM promote chromatin binding and are essential for skeletal muscle differentiation by regulating gene expression and cell cycle exit.