William J.R. Longabaugh

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

The paper establishes dynamic enhancer-based gene regulatory networks in human hematopoiesis, revealing that stemness loss and lineage acquisition are temporally and mechanistically uncoupled.

Sharing Data from the Human Tumor Atlas Network through Standards, Infrastructure, and Community Engagement

The paper describes how the Human Tumor Atlas Network shares data through standards, infrastructure, and community engagement, making datasets accessible via multiple platforms.

Systematic comparison of developmental GRNs explains how novelty is incorporated in early development

The paper compares developmental GRNs to show how novelty is incorporated while maintaining network stability during early development.

BioFabric Visualization of Network Alignments

The paper introduces a visualization tool for network alignments called VISNAB, which enhances understanding of alignment quality beyond numerical metrics.

Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis

The paper quantifies transcription factor abundances during human erythropoiesis and reveals gene regulatory principles and imbalances in coactivator-corepressor ratios.