Author

Sirui Yan

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Anthony K. L. LeungiD· 1 shared Ariana M. Angarita· 1 shared Carmen G. PaliiiD· 1 shared Clara KochendoerferiD· 1 shared Elias T. ZambidisiD· 1 shared Francis Jeffrey DilworthiD· 1 shared Isabel R. UribeiD· 1 shared Isabella VegasiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperDevelopmental Biology

Anthony K. L. LeungORCID

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2 papers

Recent·Most cited

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

Carmen G. Palii, Steven Tur, Sirui Yan, William J.R. Longabaugh, Romeo Solano, Francis Jeffrey Dilworth, Jeffrey A. Ranish, Marjorie Brand

The paper establishes dynamic enhancer-based gene regulatory networks in human hematopoiesis, revealing that stemness loss and lineage acquisition are temporally and mechanistically uncoupled.

bioRxiv · Sep 11, 2025 · PreprintGenomics

Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a PARP-DUX4 Regulatory Axis

Ludovic Zimmerlin, Ariana M. Angarita, Tea Soon Park, Rebecca Evans-Moses, Justin Thomas, Sirui Yan, Isabel R. Uribe, Isabella Vegas, Clara Kochendoerfer, Willem Buys, Anthony K. L. Leung, Elias T. Zambidis

This paper demonstrates that inhibiting PARP1 and Tankyrases in human pluripotent stem cells reprograms them to a totipotent state with lineage-specific gene expression and proteomic changes, mimicking early embryonic development.

bioRxiv · Jun 14, 2024 · PreprintDevelopmental Biology