Carmen G. Palii

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

The paper establishes dynamic enhancer-based gene regulatory networks in human hematopoiesis, revealing that stemness loss and lineage acquisition are temporally and mechanistically uncoupled.

QuickProt: A bioinformatics and visualization tool for DIA and PRM mass spectrometry-based proteomics datasets

QuickProt provides Python-based Colab notebooks for analyzing DIA and PRM proteomics data, enabling quality control, visualization, and interpretation without coding expertise.

Caspase-Activated DNase Localizes to Cancer Causing Translocation Breakpoints During Cell Differentiation

The paper identifies CAD-bound genes involved in both muscle cell differentiation and cancer-causing translocations, showing CAD-induced breaks are physiologic in differentiation and linked to oncogenic gene regulation.

Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis

The paper quantifies transcription factor abundances during human erythropoiesis and reveals gene regulatory principles and imbalances in coactivator-corepressor ratios.