Compound Mechanism of Action and Polypharmacology can be Elucidated by Large-Scale Perturbational Profile Analysis
Lucas ZhongMing Hu, Tal Hirschhorn, Stanley I. Goldstein, Diana Murray, Stephen J. Trudeau, Mikko M. Turunen, Eugene F. Douglass, Sergey Pampou, Adina Grunn, Léo Dupire, Ronald Realubit, Hai Helen Li, Alexander L.E. Wang, Hai Li, Prem S. Subramaniam, , Andrea Califano
The paper uses large-scale perturbation profiles to analyze drug mechanisms of action and polypharmacology across multiple tumor subtypes and tissues.
bioRxiv · Oct 8, 2023 · PreprintSystems Biology