Alexander L.E. Wang

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer

The paper uses a forward genetic screen in a mouse model to identify Sirtuin1 as a driver of neuroendocrine prostate cancer, showing its role in promoting NEPC and potential as a therapeutic target.

pyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data

pyVIPER is a Python package for fast, scalable rank-based enrichment analysis of scRNA-seq data, offering significant runtime improvements over VIPER for large datasets.

Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.

Compound Mechanism of Action and Polypharmacology can be Elucidated by Large-Scale Perturbational Profile Analysis

The paper uses large-scale perturbation profiles to analyze drug mechanisms of action and polypharmacology across multiple tumor subtypes and tissues.