Author

Léo Dupire

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Andrea CalifanoiD· 2 shared Adina GrunniD· 1 shared Alexander L.E. WangiD· 1 shared Andrew EmiliiD· 1 shared Barry H. HonigiD· 1 shared Brent R. StockwelliD· 1 shared Charilaos I. KanatsoulisiD· 1 shared Charles KaraniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioinformatics

Andrea CalifanoORCID

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Author profile →

2 papers

Recent·Most cited

GREmLN: A Cellular Graph Structure Aware Transcriptomics Foundation Model

Mingxuan Zhang, Vinay S. Swamy, Rowan Cassius, Léo Dupire, Charilaos I. Kanatsoulis, Evan Paull, Mohammed AlQuraishi, Theofanis Karaletsos, Andrea Califano

GREmLN is a foundation model that uses graph structure to improve gene embeddings in single-cell transcriptomics, outperforming baselines in cell type annotation and perturbation prediction.

bioRxiv · Jul 3, 2025 · PreprintBioinformatics

Compound Mechanism of Action and Polypharmacology can be Elucidated by Large-Scale Perturbational Profile Analysis

Lucas ZhongMing Hu, Tal Hirschhorn, Stanley I. Goldstein, Diana Murray, Stephen J. Trudeau, Mikko M. Turunen, Eugene F. Douglass, Sergey Pampou, Adina Grunn, Léo Dupire, Ronald Realubit, Hai Helen Li, Alexander L.E. Wang, Hai Li, Prem S. Subramaniam, , Andrea Califano

The paper uses large-scale perturbation profiles to analyze drug mechanisms of action and polypharmacology across multiple tumor subtypes and tissues.

bioRxiv · Oct 8, 2023 · PreprintSystems Biology