Prem S. Subramaniam

Compound Mechanism of Action and Polypharmacology can be Elucidated by Large-Scale Perturbational Profile Analysis

The paper uses large-scale perturbation profiles to analyze drug mechanisms of action and polypharmacology across multiple tumor subtypes and tissues.

Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis

The paper uses phosphoproteomic time-series data and the VESPA algorithm to analyze drug resistance mechanisms in colon cancer cells, revealing adaptive signaling rewiring confirmed by CRISPRko assays.

A Modular Master Regulator Landscape Determines the Impact of Genetic Alterations on the Transcriptional Identity of Cancer Cells

The paper identifies 407 Master-Regulator proteins that canalize cancer genomics into transcriptional subtypes and links genetic alterations to tumor biology through modular regulatory architectures.

Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity

The paper identifies four molecularly distinct glioblastoma subtypes using single-cell protein-activity analysis and shows drug sensitivity is state-dependent.