Cyclic-thiourea ionizable lipids program multilamellar mRNA-LNPs for sustained expression, frozen-storage stability and potent vaccine immunotherapy
Lei Zhang, Zhicheng Huang, Hao Gu, Ningze Zheng, Chunying Chen, Rong Cai, Aimin Hui
This paper introduces a cyclic-thiourea ionizable lipid (HI-62) that forms multilamellar mRNA-LNPs with sustained expression, stability, and potent vaccine immunotherapy effects.
bioRxiv · Sep 9, 2026 · PreprintBioengineering