Chunying Chen

This paper introduces a cyclic-thiourea ionizable lipid (HI-62) that forms multilamellar mRNA-LNPs with sustained expression, stability, and potent vaccine immunotherapy effects.

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.

This study shows that DNA prime-protein boost elicits enhanced antibodies against non-RBD regions of SARS-CoV-2, improving cross-neutralization against variants in mice.