Author

Hao Gu

Harvard UniversityORCID 0000-0002-0204-2875Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hao Gu2 papers · Johns Hopkins University

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Jean J. ZhaoiD· 2 shared Aimin Hui· 1 shared Bose S. KochupurakkaliD· 1 shared Changli Qian· 1 shared Cherubin ManokaraniD· 1 shared Chunying CheniD· 1 shared David LiuiD· 1 shared Elena V. IvanovaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Jean J. ZhaoORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintSep 9, 2026

Cyclic-thiourea ionizable lipids program multilamellar mRNA-LNPs for sustained expression, frozen-storage stability and potent vaccine immunotherapy

Lei Zhang, Zhicheng Huang, Hao Gu…·Aimin Hui

This paper introduces a cyclic-thiourea ionizable lipid (HI-62) that forms multilamellar mRNA-LNPs with sustained expression, stability, and potent vaccine immunotherapy effects.

DOI 10.64898/2026.09.07.749752

multiomeexperimental assay

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Cancer BiologyNature CommunicationsPeer-reviewedMay 4, 2026

Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

Xin Cheng, Y Zhang, Changli Qian…·Jean J. Zhao

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

DOI 10.1038/s41467-026-72544-z

mousebulk RNA-seq

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Cancer BiologybioRxivSep 17, 2025

Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance

Yubao Wang, Cherubin Manokaran, Yutian Zou…·Thomas M. Roberts

This study shows that PTEN loss in cancer cells activates intrinsic interferon signaling, leading to immune resistance and vulnerability to CDK12 inhibition.

1 citation

humanbulk RNA-seq

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