Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy
Diana Drago Garcia, Suvendu Giri, Rishita Chattaerjee, Arturo Simoni Nieves, Maha Abedrabbo, Alessandro Genna, Mary Luz Uribe Rios, Moshit Lindzen, Arunachalam Sekar, Nitin Gupta, Noa Aharoni, Tithi Bhandari, Agalyan Mayalagu, Luisa E. Schwarzmüller, Nooraldeen Tarade, , Yosef Yarden
The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.
bioRxiv · Feb 9, 2025 · PreprintCancer Biology