Author

Arunachalam Sekar

Weizmann Institute of ScienceORCID 0000-0002-4659-5260Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Alessandro GennaiD· 2 shared Diana Drago GarciaiD· 2 shared Eytan RuppiniD· 2 shared Feride KaratekiniD· 2 shared Nishanth Belugali NatarajiD· 2 shared Nitin Gupta· 2 shared Sima LeviD· 2 shared Suvendu GiriiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alessandro GennaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment

Abate Assefa Bashaw, Ashley D. Winters, Yuanjiu Lei, Luiza Ferreira Araujo, Do Gia Tam Vo, Arunachalam Sekar, John F. Bachman, Paige S Graves, Melissa Pineda, Jill Carol Rubinstein, Gerald S. Shadel, Marcus Bosenberg, Laura Ciaccia West, Andrew Phillip West

This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.

bioRxiv · Sep 30, 2026 · PreprintImmunology

Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy

Diana Drago Garcia, Suvendu Giri, Rishita Chattaerjee, Arturo Simoni Nieves, Maha Abedrabbo, Alessandro Genna, Mary Luz Uribe Rios, Moshit Lindzen, Arunachalam Sekar, Nitin Gupta, Noa Aharoni, Tithi Bhandari, Agalyan Mayalagu, Luisa E. Schwarzmüller, Nooraldeen Tarade, , Yosef Yarden

The paper shows that inducing epithelial traits in breast cancer cells increases autophagy and DNA damage, potentially contributing to tumor dormancy and reactivation.

bioRxiv · Feb 9, 2025 · PreprintCancer Biology

TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications

Arunachalam Sekar, Rishita Chatterjee, Boobash Raj Selvadurai, Lipika R. Pal, Aakanksha Verma, Nishanth Belugali Nataraj, Diana Drago Garcia, Suvendu Giri, Alessandro Genna, Feride Karatekin, Nitin Gupta, Mirie Zerbib, Yaron Vinik, Tamir Avioz, Eviatar Weizman, , Yosef Yarden

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.

bioRxiv · Jan 17, 2025 · PreprintCancer Biology