Attenuating LRRK2 activity ameliorates progerin-induced aging phenotypes in HGPS models and during physiological aging
Lukas Mann, Rosa Herrera-Rodriguez, Felix E van der Walt, Kyle R. Brimacombe, Shéraz Sadouki, Tom Misteli, Nard Kubben, Jan Padeken
This study shows that reducing LRRK2 activity improves aging-related defects in HGPS models and aged cells.
bioRxiv · Aug 7, 2026 · PreprintCell Biology