Author

Kyle R. Brimacombe

National Center for Advancing Translational SciencesORCID 0000-0002-9629-1417Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Matthew D. HalliD· 2 shared Ajit Jadhav· 1 shared Andrea ZalianiiD· 1 shared Anton SimeonoviD· 1 shared Dorian M. Cheff· 1 shared Ekaterina Kuznetsova· 1 shared Evgeny KulesskiyiD· 1 shared Farhan AlamiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Matthew D. HallORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 7, 2026

Attenuating LRRK2 activity ameliorates progerin-induced aging phenotypes in HGPS models and during physiological aging

Lukas Mann, Rosa Herrera-Rodriguez, Felix E van der Walt…·Jan Padeken

This study shows that reducing LRRK2 activity improves aging-related defects in HGPS models and aged cells.

DOI 10.64898/2026.08.04.742751

humanC. elegans

𝕏 PostBluesky

BioinformaticsBriefings in BioinformaticsPeer-reviewedAug 9, 2021

Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments

Ziaurrehman Tanoli, Jehad Aldahdooh, Farhan Alam…·Jing Ping Tang

MICHA is a pipeline that FAIRifies chemosensitivity assays by automatically annotating compounds, samples, reagents, and data processing methods, enabling interoperable and reusable drug screening data.

16 citations

experimental assaydatabase / resource

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Cancer BiologybioRxivPreprintOct 24, 2017

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

Nathan P. Coussens, Stephen C. Kales, Mark J. Henderson…·Matthew D. Hall

This study identifies five small molecule inhibitors of NSD2 through high-throughput screening and validates their activity in cell-based assays.

DOI 10.1101/208439

humanproteomics

𝕏 PostBluesky