Jan Padeken

This study shows that reducing LRRK2 activity improves aging-related defects in HGPS models and aged cells.

The paper identifies preprocessing bias in chromatin contact data and introduces a framework to correct it, enabling physically interpretable genome architecture reconstruction.

This study shows that inhibiting the DNMT/G9a complex targets specific epigenetic vulnerabilities in AML, inducing an IFN response and improving therapeutic outcomes.

The paper shows HPL-2 and MET-2 function in parallel H3K9me-independent pathways for gene repression and organogenesis, using distinct co-factors.

This study investigates RNA polymerase II condensates in C. elegans using simulations and experiments, showing they exhibit LCST behavior and form distinct phases during transcription.

The paper identifies a pathway in C. elegans where LSM2-8 and XRN-2 selectively degrade H3K27me3-marked genes, revealing a new layer of heterochromatin regulation in animals.