Antigen stimulation drives clonal expansion of latent CD4+ T cells using a full-length HIV latency reporter
Nnamdi M. Ikeogu, Oluwaseun Ajibola, Riley Greenslade, Wan Hon Koh, Amélie Pagliuzza, Rémi Fromentin, Michelle Perner, Roshan Parvarchian, Xinyun Liu, Paul G. Lopez, Catherine M. Card, Paul J. McLaren, Nicolas Chomont, Mario Ostrowski, Thomas T. Murooka
This study shows antigen stimulation drives clonal expansion of latent HIV-infected CD4+ T cells through TCR and co-stimulatory signals, with IL-7 and CD28 playing key roles.
bioRxiv · Sep 4, 2025 · PreprintImmunology