Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes
April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Shilin Gao, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, , Kristen Brennand
The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.
bioRxiv · Sep 19, 2026 · PreprintGenomics