Paul J. McLaren

This study shows antigen stimulation drives clonal expansion of latent HIV-infected CD4+ T cells through TCR and co-stimulatory signals, with IL-7 and CD28 playing key roles.

The paper identifies novel transcripts, eQTLs, and caQTLs in African populations and fine-maps GWAS signals for complex diseases.

The paper investigates the prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in people living with HIV and finds a higher prevalence compared to controls.

The paper investigates how human genetic variation influences Epstein-Barr virus (EBV) sequence diversity by analyzing paired viral and human genomic data from HIV-coinfected individuals.

This study identifies a genetic variant near CXCL12 associated with increased susceptibility to HIV-related non-Hodgkin lymphoma.

This paper develops a peptidome-wide association study to identify HIV epitopes linked to viral load, revealing patient-specific epitope repertoires that explain HLA-related variation in HIV control.

The paper uses polygenic methods to identify genetic overlaps between HIV acquisition and schizophrenia, ulcerative colitis, and finds potential novel variants associated with HIV.