A metabolically resistant spexin analogue, LIT-01-144, induces potent non-opioid peripheral antinociception in persistent pain via activation of GALR2
Yann Berthomé, Glenn-Marie Le Coz, Valérie Utard, Qiuxiang Gu, Rosine Fellmann-Clauss, Nathalie Petit-Demoulière, Raphäelle Quillet, Claire Gavériaux‐Ruff, Sridévi M. Ramanoudjame, Lucie Estéoulle, Nicolas Humbert, François Daubeuf, Patrick Gizzi, Stéphanie Riché, Xavier Leroy, , Frédéric Simonin
This study develops a spexin analog, LIT-01-144, that activates GALR2 to provide potent non-opioid antinociception in persistent pain without central nervous system penetration.
bioRxiv · Feb 20, 2026 · PreprintPharmacology & Toxicology