Mechanical tuning of replication stress tolerance and genomic stability through the checkpoint mediator Mrc1
Adam J. Timmerman, Rowan E. Brady, Via M Lawson, Joseph A. Stewart, Juan Lucas Argueso, Grant D. Schauer
This study shows Mrc1 balances replication fork stability and flexibility by linking CMG helicase and Pol2, and its phosphorylation alters this balance under checkpoint activation.
bioRxiv · May 16, 2026 · PreprintBiochemistry