Juan Lucas Argueso

This study shows Mrc1 balances replication fork stability and flexibility by linking CMG helicase and Pol2, and its phosphorylation alters this balance under checkpoint activation.

This study shows that Candida glabrata replicating inside macrophages experiences amino acid deprivation, DNA damage, and chromosome instability, with mutations in RME1 enhancing its survival.

The paper identifies a bias for chromosomal rearrangements at the right arm of Chr7 in yeast, showing that this bias is due to inefficient repair rather than increased breakage.

The paper analyzes mtDNA damage fragments from three species after UV exposure, finding characteristic length profiles and di-pyrimidine patterns suggesting novel repair mechanisms.

The paper identifies two distinct pathways of genome rearrangement induced by multi-invasion during homologous recombination and their impact on genome stability.

The paper shows that stochastic genomic instability in yeast leads to phenotypic and genomic diversification through transient bursts of structural variations.

The paper presents a comprehensive genomic structural analysis of a pathogenic S. cerevisiae isolate using long-read sequencing, revealing extensive structural variation and its implications for genomic stability and development.

The paper identifies systemic aneuploidization events as the cause of phenotype switching in Saccharomyces cerevisiae, showing that stochastic chromosome copy number changes drive morphological variation.

The paper characterizes bursts of genome-wide loss-of-heterozygosity in budding yeast, showing non-independent mutation accumulation and systemic genomic instability.

This study investigates how aneuploidies arise in budding yeast, finding that loss of one chromosome often leads to additional unselected aneuploidies, resulting in complex genomic changes.

This paper develops a yeast experimental system to study meiotic NAHR and CNV formation, finding that larger LCRs increase CNV frequency and interhomolog NAHR is overrepresented.

The paper identifies systemic genomic instability in yeast, showing non-independent accumulation of loss-of-heterozygosity events across multiple chromosomes.

This study shows that Spn1, a chromatin-binding protein in yeast, promotes genome instability by favoring the translesion synthesis pathway over template switch during DNA damage tolerance.