Combined deletion of cytosolic 5'-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and by lowering hepatic glucose production
Roxane Jacobs, Gaëtan Herinckx, Noémie Galland, Clémence Balty, Didier Vertommen, Mark H. Rider, Manuel Johanns
The paper shows that deleting both NT5C1A and NT5C2 in mice lowers blood sugar by improving muscle insulin response and reducing liver glucose production.
Journal of Biological Chemistry · Feb 11, 2025Peer-reviewedPhysiology