Gaëtan Herinckx

Stage-dependent tau post-translational modifications map the spatiotemporal progression of Alzheimer's disease

This study maps stage-dependent tau post-translational modifications across Alzheimer's disease progression, revealing early phosphorylation and later ubiquitination events associated with tau aggregation.

Cardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption

This study shows that cardiovirus L protein disrupts nucleocytoplasmic trafficking, leading to PKR inhibition by sequestering PKR in nucleoli and releasing nuclear RNA-binding proteins into the cytosol.

Conserved phosphorylatable residues in motif G of positive-stranded virus RdRps regulate polymerase activity and suggest targets for drug design.

This study identifies conserved phosphorylatable residues in motif G of viral RdRps that inhibit polymerase activity and suggests they as targets for antiviral drugs.

The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ϵ/REV-ERBα/Transgelin Signaling Pathway.

This study identifies a circadian clock-controlled signaling pathway that drives hepatic stellate cell activation in liver fibrosis, offering potential drug targets and a basis for chronotherapeutic strategies.

Combined deletion of cytosolic 5'-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and by lowering hepatic glucose production

The paper shows that deleting both NT5C1A and NT5C2 in mice lowers blood sugar by improving muscle insulin response and reducing liver glucose production.