Human and Rodent Temporal Lobe Epilepsy is Characterized by Changes in O-GlcNAc Homeostasis that can be Reversed to Dampen Epileptiform Activity
Richard G. Sánchez, R. Ryley Parrish, Megan C. Rich, William M. Webb, Roxanne M. Lockhart, Kazuhito Nakao, Lara Ianov, Susan C. Buckingham, Devin R. Broadwater, Alistair J. Jenkins, Nihal C. de Lanerolle, Mark O. Cunningham, Tore Eid, Kristen Owen Riley, Farah D. Lubin
This study shows that O-GlcNAc homeostasis is disrupted in TLE and that inhibiting OGA can reverse these changes and reduce seizures.
Neurobiology of Disease · Jan 6, 2019Peer-reviewedNeuroscience