The PGC-1α Gly482Ser rs8192678 SNP reprograms oxidative metabolism to favor energy storage in females
Maria Galipeau, Nathalie Jouvet, Matthieu Schoumacher, Émilie Courty, Roxanne Vandenbeek, Aysim Güneş, Martin Braud, Cynthia Fourgeux, Jérémie Poschmann, Francis C. Lynn, May Faraj, Jennifer L. Estall
This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.
bioRxiv · Oct 22, 2026 · PreprintPhysiology