Francis C. Lynn

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

This study shows that MED15 is continuously required after weaning to maintain functional β-cell maturity in mice.

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

This study compares immature stem-cell-derived β-cells to primary β-cells using multi-omic single-cell methods, identifying SREBP1 as a target for improving β-cell maturation.

The paper generates and validates an AHR knockout human embryonic stem cell line to study AHR's role in islet development.

This study shows that Npas4 in POMC neurons regulates food intake during obesity by modulating inhibitory GABA-A receptor expression and neuronal activity.

The paper identifies fibroblast growth factors (FGFs) as protective for human stem cell-derived insulin-secreting beta cells through a medium-throughput screen.

This study investigates AHR-HIF1 pathway crosstalk in islet cells and finds hypoxia suppresses CYP1A1 and G6PC2 expression, with HIF1 dominating over AHR during TCDD + hypoxia co-treatment.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

The paper develops a dual fluorescent reporter hESC line to track insulin- and glucagon-expressing cells during differentiation, revealing bihormonal cells preferentially become alpha-like.

The paper identifies small molecules that enhance stem cell differentiation into definitive endoderm, reducing costs by 90% through a drug repurposing approach.

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

This study profiles single-cell transcriptomes of mouse and hESC-derived endocrine progenitors to identify markers and cell-state populations relevant to beta-cell formation.

This study identifies chromatin-state signatures linked to β-cell dysfunction and diabetes by combining epigenome mapping with single-cell transcriptomics in mice and humans.