Jérémie Poschmann

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

The paper investigates TDG's role in cell differentiation by showing its involvement in ATF4-dependent gene transcription during retinoic acid-induced neural fate commitment.

The paper identifies a dynamic gene regulatory network in Duchenne muscular dystrophy that controls cell fate decisions and shows how disease mutations disrupt this network.

This study identifies PU.1 as a key transcription factor regulating epigenetic responses to Mtb, showing its role in supporting infection and potential as a therapeutic target.

This study identifies two clusters of severe mental disorder patients with differing illness severity, finding elevated pro-inflammatory serum proteins in the more severe group.

The paper shows that sperm-derived H2AK119ub1 is essential for embryonic development in Xenopus laevis by guiding epigenetic remodelling of paternal chromatin.

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

This study generates functional thymic epithelial cells from iPSCs that support T cell development and dendritic cell differentiation in vitro.

SCellBOW identifies and risk-stratifies tumor cell subpopulations using scRNA-seq data by simulating their impact on disease prognosis.

The paper identifies transcriptional regulatory networks during human cardiac development by analyzing transcriptomic profiles and uncovering novel interactions among key transcription factors.

This study identifies widespread H3K27ac acetylomic variation in AD cases compared to controls, linking it to disease-related pathways and AD-associated genetic variants.