Ancient pyroptotic machinery via GSDMA/B cleavage by LPS-activated caspase-1 in cartilaginous fish
Xuxia Wei, Ru Zhuang, Xueqin Jia, Xinli Wang, Sen Li, Ziwen Huang, Gaijing Zhou, Anlong Xu, Shaochun Yuan
This study identifies a non-canonical pyroptosis pathway in cartilaginous fish involving GSDMA/B cleavage by LPS-activated caspase-1, revealing dual-fragment regulation and antimicrobial activity.
bioRxiv · Jul 8, 2026 · PreprintEvolutionary Biology