Merkel cell polyomavirus infection and persistence modelled in skin organoids
Silvia Albertini, Manja Czech‐Sioli, Thomas Günther, Sanamjeet Virdi, Patrick Blümke, Lisann Röpke, Veronika Brinschwitz, Maura Dandri, Lena Allweiss, Rudolf Reimer, Carola Schneider, Arne Hansen, Susanne Krasemann, Emanuel Wyler, Markus Landthaler, , Nicole Fischer
This paper demonstrates that iPSC-derived skin organoids support MCPyV infection, persistence, and tumor development, providing a model to study viral interactions with the immune system and treatment strategies.
bioRxiv · Feb 11, 2025 · PreprintMolecular Biology