Carola Schneider

Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy

This paper develops a CD7-targeted rAAV vector for efficient gene delivery to human T and NK cells, showing reduced off-target effects and improved transgene expression through genome optimization.

The nuclear egress complex of MHV-68 is not essential for nuclear egress but mediates C-capsid specificity

This study shows that the MHV-68 nuclear egress complex (NEC) is not essential for nuclear egress but mediates C-capsid specificity, allowing some capsids to exit the nucleus through alternative pathways.

A PROPPIN links V-ATPase assembly to endocytic membrane dynamics in malaria parasites

This study identifies PfATG18 as a regulator of vacuolar membrane dynamics in malaria parasites, linking V-ATPase assembly to endocytic processes and drug resistance.

Amphisome biogenesis couples synaptic autophagy to local protein synthesis

The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.

Merkel cell polyomavirus infection and persistence modelled in skin organoids

This paper demonstrates that iPSC-derived skin organoids support MCPyV infection, persistence, and tumor development, providing a model to study viral interactions with the immune system and treatment strategies.

Complex Human hear bearing Skin Organoids reveal Cell Type Specific Susceptibility and Innate Immune Responses to Herpes Simplex Virus 1

This study uses human hair-bearing skin organoids to investigate HSV-1 infection and host responses, revealing cell-type-specific susceptibility and spatially organized immune reactions.

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

This study identifies a novel function of MCPyV small T antigen in suppressing the type I interferon response by reducing IRF9 levels, impacting immune evasion and tumor progression.

BRAIN-DERIVED EXTRACELLULAR VESICLES ARE HIGHLY ENRICHED IN THE PRION PROTEIN AND ITS C1 FRAGMENT: RELEVANCE FOR CELLULAR UPTAKE AND IMPLICATIONS IN STROKE

This study characterizes brain-derived extracellular vesicles (sEVs) in mice under normal and post-stroke conditions, showing increased PrP and PrP-C1 content and altered cellular uptake.