Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer Disease
Nathan J Sahelijo, Priya Rajagopalan, Qian Lu, Rufuto Rahman, Dhawal Priyadarshi, Daniel Goldstein, Sophia I. Thomopoulos, David A. Bennett, Lindsay A. Farrer, Thor D. Stein, Li Shen, Heng Huang, Kwangsik T. Nho, Andrew J. Saykin, Christos A. Davatzikos, , Gyungah Jun
This study identifies genetic subtypes of Alzheimer's Disease using cell-based gene networks and polygenic risk scores, then repositions existing drugs for AD treatment.
medRxiv · Jun 21, 2024 · PreprintGenetic & Genomic Medicine