Lmna deficiency promotes EPHX2 nuclear translocation to ameliorate cardiac dysfunction in mice
Congting Guo, Ze Wang, Jiayi Liu, Chenyang Wu, Yuhan Yang, Zhengyuan Lv, Gonglie Chen, Yueshen Sun, Ruilian Bai, Weiyan Sun, Tian Lu, Kai Wang, Z Tian, Xu Zhang, Dongyu Zhao, , Yuxuan Guo
This paper identifies EPHX2 nuclear translocation as a mechanism to ameliorate cardiac dysfunction in Lmna-deficient mice using AAV-Cas9-based gene editing.
bioRxiv · Feb 10, 2026 · PreprintPathology