Gonglie Chen

This paper identifies EPHX2 nuclear translocation as a mechanism to ameliorate cardiac dysfunction in Lmna-deficient mice using AAV-Cas9-based gene editing.

This paper develops a synergistic RNA switch system that enhances gene expression control by integrating multiple regulatory modules, achieving improved inducibility and reduced off-target effects.

This study shows neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican, identified through co-culture experiments and functional assays.

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.