Yuxuan Guo

Lmna deficiency promotes EPHX2 nuclear translocation to ameliorate cardiac dysfunction in mice

This paper identifies EPHX2 nuclear translocation as a mechanism to ameliorate cardiac dysfunction in Lmna-deficient mice using AAV-Cas9-based gene editing.

Synergistic integration of inducible RNA switches enhances the manipulation of vector expression

This paper develops a synergistic RNA switch system that enhances gene expression control by integrating multiple regulatory modules, achieving improved inducibility and reduced off-target effects.

AAV vectors with enhancer-controlled ITR promoters

This paper designs AAV vectors with enhancer-controlled ITR promoters to improve payload capacity and enable tissue-specific gene editing with a single AAV.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system

This study shows neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican, identified through co-culture experiments and functional assays.

An all-in-one AAV vector for cardiac-specific gene silencing by an adenine base editor

This study shows that single-AAV delivery of base editors can achieve effective cardiac gene silencing with higher success rates than dual-AAV systems.

Myocardial infarction creates a critical time window for AAV gene therapy

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.

ZNHIT1-dependent H2A.Z deposition at meiotic prophase I underlies pachytene gene expression and meiotic progression during male meiosis

This study identifies ZNHIT1's role in meiotic progression by regulating H2A.Z deposition and gene expression during pachytene in male meiosis.

In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury

This study identifies PALMD as a Z-line-associated protein that mitigates cardiac injury through stabilization of NEXN using in vivo proximity proteomics.

Sarcomeres regulate cardiomyocyte maturation through MRTF-SRF signaling

This study shows that sarcomere assembly via ACTN2 and MRTF-SRF signaling promotes cardiomyocyte maturation through a positive feedback loop.

In vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation