Yuhan Yang

This paper identifies EPHX2 nuclear translocation as a mechanism to ameliorate cardiac dysfunction in Lmna-deficient mice using AAV-Cas9-based gene editing.

This paper develops a synergistic RNA switch system that enhances gene expression control by integrating multiple regulatory modules, achieving improved inducibility and reduced off-target effects.

This study shows neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican, identified through co-culture experiments and functional assays.

This study shows that single-AAV delivery of base editors can achieve effective cardiac gene silencing with higher success rates than dual-AAV systems.