PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in mice
Chao Wei, Xiaoyuan Yan, Jeffrey M. Mann, Ruirong Geng, Qianyi Wang, Huirong Xie, Elena Y. Demireva, Liangliang Sun, Deqiang Ding, C. Chen
This study shows that PNLDC1 is essential for piRNA 3' end trimming, LINE1 silencing, and spermatogenesis in mice, with pachytene piRNA trimming being critical for germ cell development.
PLoS Genetics · Sep 23, 2024Peer-reviewedDevelopmental Biology