Author

Xiaoyuan Yan

Michigan State UniversityPrimary ORCID profile (0000-0001-8645-4836 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Xiaoyuan YaniD1 paper · Chinese Academy of Sciences

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

C. CheniD· 2 shared Chao WeiiD· 2 shared Deqiang DingiD· 2 shared Elena Y. DemirevaiD· 2 shared Huirong XieiD· 2 shared Jeffrey M. ManniD· 2 shared Liangliang SuniD· 2 shared Qianyi WangiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 44 mutual co-author links

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2 shared papersDevelopmental Biology

C. ChenORCID

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2 papers

Recent·Most cited

Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization

Xiaoyuan Yan, Chao Wei, Jeffrey M. Mann, Guanyi Shang, Qianyi Wang, Huirong Xie, Elena Y. Demireva, Liangliang Sun, Deqiang Ding, C. Chen

This study identifies mitochondrial scaffolds that regulate PIWI protein trafficking and pachytene piRNA biogenesis in mice, revealing a central role for chromatoid body precursors in piRNA complex formation.

Proceedings of the National Academy of Sciences · May 12, 2026Peer-reviewedDevelopmental Biology

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in mice

Chao Wei, Xiaoyuan Yan, Jeffrey M. Mann, Ruirong Geng, Qianyi Wang, Huirong Xie, Elena Y. Demireva, Liangliang Sun, Deqiang Ding, C. Chen

This study shows that PNLDC1 is essential for piRNA 3' end trimming, LINE1 silencing, and spermatogenesis in mice, with pachytene piRNA trimming being critical for germ cell development.

PLoS Genetics · Sep 23, 2024Peer-reviewedDevelopmental Biology