C. Chen

Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization

This study identifies mitochondrial scaffolds that regulate PIWI protein trafficking and pachytene piRNA biogenesis in mice, revealing a central role for chromatoid body precursors in piRNA complex formation.

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in mice

This study shows that PNLDC1 is essential for piRNA 3' end trimming, LINE1 silencing, and spermatogenesis in mice, with pachytene piRNA trimming being critical for germ cell development.