Xenopus IgX informs engineering strategies of IgM and IgG hexamers
Ruixue Zhang, Chenggong Ji, Shuhan Li, Ningning Li, Ning Gao, Junyu Xiao
The paper presents the cryo-EM structure of Xenopus IgX, revealing a hexameric assembly that informs strategies for engineering human IgM and IgG hexamers with therapeutic applications.
Science Advances · Nov 5, 2025Peer-reviewedImmunology