Functional modules predict genetic interactions, revealing evolutionary conservation and rewiring
Chenchu Lin, Veronica Gheorghe, Juihsuan Chou, Sabriyeh Alibai, Subin Kim, Nazanin Esmaeili Anvar, Yixin Xu, Xingdi Ma, Lori Wilson, Russell D. Moser, Christopher J. Kemp, Jun Chen, Scott Kopetz, Traver Hart
The paper identifies human gene modules enriched for genetic interactions using a combinatorial knockout platform and validates their conservation and rewiring across cancer cell lines.
bioRxiv · Sep 22, 2026 · PreprintSystems Biology