Clonal overlap and convergent clustering of T-cell receptor signatures in Crohn's disease in monozygotic twins
Eelco Christiaan Brand, Romi Vandoren, Lisanne Lutter, Vincent M.L. Van Deuren, Nila H. Servaas, Aridaman Pandit, Pieter Meysman, Bas Oldenburg, Femke van Wijk, Pieter Honkoop, Rutger J Jacobs, Bart L M Müskens, Cyriel Y. Ponsioen, Nanne K.H. de Boer, Yasser A. Alderlieste, , Marielle J L Romberg-Camps
This study analyzes T-cell receptor repertoires in monozygotic twins with and without Crohn's disease, finding increased TCR overlap in concordant pairs and identifying eight novel TCR clusters potentially linked to the disease.
Inflammatory Bowel Diseases · Apr 14, 2026Peer-reviewedImmunology