Femke van Wijk

This study examines how dupilumab and upadacitinib affect epigenetic and transcriptomic changes in skin-homing T cells of atopic dermatitis patients over one year of treatment.

The paper identifies dysregulated dsRNA sensing and RNA viral exposure as potential triggers of type I interferon dysregulation in juvenile dermatomyositis onset.

This study analyzes T-cell receptor repertoires in monozygotic twins with and without Crohn's disease, finding increased TCR overlap in concordant pairs and identifying eight novel TCR clusters potentially linked to the disease.

This study shows neonatal human naive CD4+ T cells have higher CD38 expression, linking it to glycolytic metabolism and tolerogenic function compared to adult cells.

The paper introduces AIRRWAS, a framework to identify T cell receptor convergence with bacterial genera, revealing reproducible associations across cohorts and functional T cell responses.