Vincent M.L. Van Deuren

This paper introduces NanoBlocks, a method to convert affinity binders into fluorescent biosensors by adding competitive peptides, demonstrating their use in detecting targets in vitro and in cells.

This paper introduces RSpFAST, a non-covalent chemogenetic platform for fluorescence imaging, and demonstrates its dual behavior as a stable label and a reversible photoswitcher.

The paper introduces a computational framework to efficiently identify significantly neighbor enriched TCR sequences, demonstrating its utility in analyzing memory T cells and T cell responses to vaccination and viral infections.

This study analyzes T-cell receptor repertoires in monozygotic twins with and without Crohn's disease, finding increased TCR overlap in concordant pairs and identifying eight novel TCR clusters potentially linked to the disease.

This study tracks CD4+ T cell and IgG responses over time after yellow fever vaccination, showing peak activation at day 22 and long-term antibody persistence.

The paper introduces AIRRWAS, a framework to identify T cell receptor convergence with bacterial genera, revealing reproducible associations across cohorts and functional T cell responses.

The paper creates a synovial fluid TCR, cytokine, and cell repertoire atlas to compare disease mechanisms across arthritic conditions using systems immunology approaches.

The paper links immunotypes and enterotypes through a systems immunology approach, showing they are orthogonal and connected via the blood transcriptome, with associations between specific bacteria and immune health.

The paper analyzes the sequence distribution of epitope-specific TCR repertoires and shows how this affects machine learning model performance.

RapTCR provides a tool for rapid visualization and analysis of T-cell receptor repertoires, capturing both global and local sequence similarities.