Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal
Koray Dogan Kaya, Holly Y. Chen, Matthew J. Brooks, Ryan A. Kelley, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Charles T. Drinnan, Linn M. Gieser, Kamil Kruczek, Slaven Erceg, Tiansen Li, Dunja Lukovic, Yogita K. Adlakha, Emily Welby, Anand Swaroop
Comparing retinal organoid transcriptomes against human fetal and adult retina places each culture on a developmental scale; replacing all-trans retinoic acid with 9-cis retinal sped rod differentiation.
bioRxiv · Aug 12, 2019 · PreprintDevelopmental Biology