This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

bioRxiv · May 1, 2024 · PreprintCell Biology

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

Holly Y. Chen, Manju Swaroop, Samantha Papal, Anupam Kumar Mondal, Hyun Beom Song, Laura Campello, Gregory J. Tawa, Florian Régent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G. Jacobson, Wei Zheng, Anand Swaroop

This study identifies reserpine as a drug candidate that improves photoreceptor survival in retinal ciliopathies by restoring proteostasis and ciliogenesis.

eLife · Mar 28, 2023Peer-reviewedGenetic & Genomic Medicine

Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal

Koray Dogan Kaya, Holly Y. Chen, Matthew J. Brooks, Ryan A. Kelley, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Charles T. Drinnan, Linn M. Gieser, Kamil Kruczek, Slaven Erceg, Tiansen Li, Dunja Lukovic, Yogita K. Adlakha, Emily Welby, Anand Swaroop

Comparing retinal organoid transcriptomes against human fetal and adult retina places each culture on a developmental scale; replacing all-trans retinoic acid with 9-cis retinal sped rod differentiation.

bioRxiv · Aug 12, 2019 · PreprintDevelopmental Biology