ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM
Sara González-Hernández, Ryo Sato, Yuya Sato, Chang Liu, Wenling Li, Zulfeqhar Ali Syed, Chengyu Liu, Sadhana Jackson, Yoshiaki Kubota, Yoh‐suke Mukouyama
This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.
JCI Insight · Jan 1, 2026Peer-reviewedDevelopmental Biology