Yoshiaki Kubota

This study identifies CTHRC1 as a protective factor in valvular interstitium that limits macrophage-driven calcification in aortic valve disease.

This study shows that activating YAP/TAZ improves bone marrow niche recovery and hematopoietic regeneration after myeloablative stress.

The paper develops REFLEX and HUNTERuni-seq to identify perivascular angiogenic macrophages (PVAMs) that deliver VEGF-A to endothelial cells, showing physical contact is critical for effective signaling.

This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.

This study identifies a sympathoadrenal origin for the renal segment of the inferior vena cava in mice, challenging the classical mesonephros-centric model and explaining anatomical variations.

This study identifies embryonic origins and hypoxia-driven mechanisms in PIK3CA-driven vascular malformations, showing that HIF-1 and VEGF-A inhibition reduces abnormalities.

This study identifies Scarb1-mediated endothelial-fibroblast interactions as a driver of EndMT and heart failure progression, showing that targeting Scarb1 can improve cardiac function.

This study investigates the role of TIE1 and its interaction with TIE2 in venous development, finding that TIE1 restricts angiogenic sprouting to coordinate vein formation.

This study identifies partial endothelial-to-mesenchymal transition (EndMT) as a mechanism contributing to lumen re-organization after carotid artery ligation.