ImmunologybioRxivPreprint
EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection
M. Pinilla, R. Mazars, R. Verge…·E. Meunier
This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.
DOI 10.1101/2023.01.16.524164