Author

F. L. Zhong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 7

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:rat· 1

Frequent Co-Authors

G. A. TOH· 4 shared K. Robinson· 3 shared K. S. ROBINSON· 3 shared P. Rozario· 3 shared B. Reversade· 2 shared B. Wu· 2 shared C. BONNARD· 2 shared C. K. LIM· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

G. A. TOH

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells

F. L. Zhong, P. Rozario, M. Pinilla, A. C. Vind, K. Robinson, T. Gee Ann, M. Jasrie Firdaus, J. Francisco Martinez, L. Zhewang, S. Bekker-Jensen, E. Meunier

This study identifies the mechanism by which nigericin activates the NLRP1 inflammasome in human epithelial cells through potassium efflux and ribotoxic stress response.

bioRxiv · Jun 23, 2023 · PreprintImmunology

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

M. Pinilla, R. Mazars, R. Verge, L. Gorse, K. Santoni, K. S. Robinson, G. A. Toh, L. Prouvensier, S. A. Leonicaza, A. Hessel, d. pericat, M. Murris, A. Henras, J. M. Buyck, C. Cougoule, , E. Meunier

This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.

bioRxiv · Jan 16, 2023 · PreprintImmunology

Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria

K. S. ROBINSON, G. A. TOH, M. J. FIRDAUS, K. C. THAM, P. ROZARIO, C. LIM, Y. X. TOH, Z. H. LAU, S. C. BINDER, J. MAYER, C. BONNARD, F. I. SCHMIDT, J. A. COMMON, F. L. ZHONG

This paper shows that Corynebacterium diphtheriae toxin activates NLRP1 inflammasome and pyroptosis in keratinocytes via ribotoxic stress response pathways.

bioRxiv · Jan 16, 2023 · PreprintImmunology

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

K. S. ROBINSON, G. A. TOH, P. ROZARIO, S. BAYAT, Z. SUN, S. BAUERNFRIED, R. NADKARNI, C. R. HARAPAS, C. K. LIM, W. CHU, K. Y. TAN, C. BONNARD, R. SOBOTA, J. E. CONNOLLY, S. L. MASTERS, , F. L. Zhong

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

bioRxiv · Jan 24, 2022 · PreprintImmunology

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epithelium

K. Robinson, D. E. T. Teo, K. S. Tan, G. A. Toh, H. H. Ong, C. K. Lim, K. Lay, B. V. Au, T. S. Lew, J. J. H. Chu, V. T. K. Chow, D. Y. Wang, F. L. Zhong, B. Reversade

The paper identifies enteroviral 3C proteases as the first cognate PAMP ligand for human NLRP1, showing they trigger inflammasome activation and airway inflammation.

bioRxiv · Oct 14, 2020 · PreprintImmunology

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

M. Huang, X. Zhang, T. G. Ann, Q. Gong, J. Wang, Z. Han, B. Wu, F. L. Zhong, J. Chai

This study identifies the structural and biochemical mechanism by which DPP9 inhibits NLRP1, preventing its activation and maintaining it in an auto-inhibited state.

bioRxiv · Aug 13, 2020Immunology

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

Q. Gong, K. Robinson, C. Xu, J. Zhang, Z. Z. Boo, D. E. T. Teo, Y. Zhang, J. S. Y. Lim, W. I. Goh, G. Wright, F. L. Zhong, B. Wu, B. Reversade

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

bioRxiv · Jun 17, 2020Immunology